FGF-19 is secreted from the intestinal epithelial cells in response to bile acids released to the intestinal lumen upon feeding. FGF-19 promotes glucose uptake in adipocytes and has a role in bile acid homeostasis and hepatic protein metabolism. FGF-19 levels in the blood can be used to assess liver and gastrointestinal function, and may be a target for the treatment of metabolic disorders.
References:
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Johnston, I.M., Nolan, J.D., Pattni, S.S., Appleby, R.N., Zhang, J.H., Kennie, S.L., Madhan, G.K., Jameie-Oskooei, S., Pathmasrirengam, S., Lin, J. and Hong, A., 2016. Characterizing factors associated with differences in FGF19 blood levels and synthesis in patients with primary bile acid diarrhea. Official journal of the American College of Gastroenterology| ACG, 111(3), pp.423-432.